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Rare side effects of B12 shots (require medical attention) Serious reactions to B-12 shots are uncommon, but its important to be aware of them: Allergic reaction, including rash, hives, dizziness, or trouble breathing Significant swelling, pain, or warmth that worsens at the injection site Palpitations or chest discomfort Signs of drug interactions, especially if you take multiple prescription medications If you experience symptoms that feel intense, progressive, or unusual, you should contact your provider right away

The FASEB Journal, 2019

GST-M1*0F requencies range from 42-60% in Caucasians [111] and GST-M1*0 appears to be associated with social behavioural changes in mice compared to wild type [112]